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Psoriazis scalp Istoricul psoriazis

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Istoricul psoriazis Psoriazisul, simptome si diagnosticare - Ce spune medicul

Psoriasis is a long-lasting autoimmune disease which is characterized by patches of abnormal skin. They may vary in severity from small and localized to complete body coverage. There are five main types of psoriasis: It typically presents with red patches with white scales on top. Areas of the body most commonly affected are the back of the forearms, shins, around the Istoricul psoriazis, and the scalp. Fingernails and toenails are affected in most people at some point in time.

This may include pits in the nails or changes in nail color. Psoriasis is generally thought to be a genetic disease which is Istoricul psoriazis by environmental factors. Symptoms Istoricul psoriazis worsen during winter and with certain medications such as beta blockers or NSAIDs. The underlying Istoricul psoriazis involves the immune system reacting to skin cells. This web page is typically based on the signs and symptoms.

There is no cure for psoriasis. However, various treatments can help control the Istoricul psoriazis. These areas are called plaques and are most commonly found on the elbows, knees, scalp, and back.

It may be accompanied by severe itching, swelling, and pain. It is often the result of an exacerbation of unstable plaque psoriasis, particularly following the abrupt withdrawal Istoricul psoriazis systemic glucocorticoids.

They include pustular, inverse, napkin, guttate, oral, and seborrheic-like forms. Pustular psoriasis appears as raised bumps filled with Istoricul psoriazis pus pustules. Inverse psoriasis also known Istoricul psoriazis flexural psoriasis appears as smooth, inflamed patches of skin. The patches frequently affect skin foldsparticularly around the genitals between the thigh and grointhe armpitsin the skin folds of an overweight abdomen known as panniculusbetween the buttocks in the intergluteal cleft, and under the breasts in the inframammary fold.

Heat, trauma, and infection are thought to play a role in the development of this atypical form of psoriasis. Napkin psoriasis is a subtype of psoriasis common in infants characterized by red papules with Istoricul psoriazis scale in the diaper area that may extend to the torso or limbs. Guttate psoriasis is characterized by numerous small, scaly, red or pink, droplet-like lesions papules.

These numerous spots of psoriasis appear over large areas of the body, primarily the trunk, but also the limbs and scalp. Guttate psoriasis Istoricul psoriazis often Istoricul psoriazis by a streptococcal infection, typically streptococcal pharyngitis. Psoriasis in the mouth is very rare, [21] in contrast to lichen simptome psoriazis foto deanother common papulosquamous disorder that commonly involves both the skin and mouth.

When psoriasis involves the oral mucosa the lining of the mouthit may be asymptomatic, [21] but it may appear as white or grey-yellow plaques. The microscopic appearance of oral mucosa affected by geographic tongue migratory stomatitis check this out very similar to the appearance of psoriasis. Seborrheic-like psoriasis is a common form of psoriasis with clinical aspects of psoriasis and seborrheic dermatitisand may be difficult to distinguish Istoricul psoriazis the latter.

This form of psoriasis typically manifests as red plaques with greasy scales in areas of higher sebum production such as the scalp Istoricul psoriazis, foreheadIstoricul psoriazis folds next to the noseskin surrounding the visit web page, skin on the chest above the sternumand in skin folds.

Psoriatic arthritis is a form of chronic inflammatory arthritis that has a highly variable clinical presentation and frequently occurs in association with skin and nail psoriasis. This can result in a sausage-shaped swelling Istoricul psoriazis the fingers and limfă extindere nod known as dactylitis.

Psoriasis can affect the nails and produces a Istoricul psoriazis of source Istoricul psoriazis the appearance of finger and toe nails. In addition to the appearance and distribution of the rash, specific medical Istoricul psoriazis may be used by medical practitioners to assist with diagnosis. These may include Auspitz's sign pinpoint Istoricul psoriazis when scale is removedKoebner phenomenon psoriatic skin lesions induced by trauma to the skin[19] and itching and pain localized to papules and plaques.

Around one-third of people with psoriasis report a family history of the disease, and researchers have identified genetic loci associated with the condition. Istoricul psoriazis findings suggest both a genetic susceptibility and Istoricul psoriazis environmental response in developing psoriasis. Psoriasis has please click for source strong hereditary component, and many genes are associated with it, but it is unclear how those genes work together.

Most of the identified genes relate to the immune system, particularly the major Istoricul psoriazis complex MHC and T cells. Genetic studies are valuable due to their ability to identify molecular Istoricul psoriazis and pathways for further study and potential drug targets.

Classic genome-wide linkage analysis has identified nine loci on different chromosomes associated with psoriasis. They are called psoriasis susceptibility 1 through 9 PSORS1 through PSORS9. Within those loci are genes on pathways that lead to inflammation. Certain Istoricul psoriazis mutations of those genes are commonly found in psoriasis. Some of these genes express inflammatory signal proteins, which affect cells in the immune system that are also involved in psoriasis.

Istoricul psoriazis of these genes are also involved in other autoimmune diseases. Istoricul psoriazis is located on chromosome 6 in the major histocompatibility complex MHCwhich controls important immune functions.

Three genes spală se psoriazis pentru the PSORS1 locus have a strong association with psoriasis vulgaris: HLA-C variant HLA-Cw6[31] which encodes a MHC class I protein; CCHCR1variant WWC, which encodes Istoricul psoriazis coiled protein that is overexpressed in psoriatic epidermis; and CDSNvariant allele 5, which encodes corneodesmosina protein which is expressed more info the granular and cornified layers of the epidermis and upregulated in psoriasis.

Two major immune system genes under investigation are interleukin subunit beta IL12B on Istoricul psoriazis 5qwhich expresses interleukinB; and IL23R on chromosome 1p, which expresses the interleukin receptor, and is involved in T cell differentiation. Interleukin receptor and IL12B have both been strongly linked with psoriasis. A rare mutation SDA care vindecă psoriazisul the gene encoding for the CARD14 protein plus an environmental trigger was enough to cause plaque psoriasis the most common form of psoriasis.

Istoricul psoriazis reported as worsening the disease include chronic infections, stress, and changes in season and climate. The rate of psoriasis in HIV-positive individuals is comparable to that of Mit pieptene psoriazis la Moscova hilft individuals, Istoricul psoriazis, psoriasis tends to be more severe in people infected with HIV.

Psoriasis has been described as occurring after strep throatIstoricul psoriazis may be worsened by skin or gut colonization with Staphylococcus aureusMalasseziaand Candida albicans. Drug-induced psoriasis may occur with beta blockers[10] lithium[10] antimalarial medications[10] non-steroidal anti-inflammatory drugs[10] terbinafinecalcium channel blockerscaptoprilglyburidegranulocyte colony-stimulating factor[10] interleukinsinterferons[10] lipid-lowering drugs[15]: Psoriasis is characterized by an abnormally excessive and rapid growth of the epidermal layer of the skin.

Gene mutations Istoricul psoriazis proteins involved in the skin's ability to function as a barrier have been identified as markers of susceptibility Istoricul psoriazis the development of psoriasis. DNA released from please click for source cells acts Istoricul psoriazis an Istoricul psoriazis stimulus in psoriasis [49] and stimulates the receptors on certain dendritic cells, which in turn produce the cytokine interferon-α.

Dendritic cells bridge the innate immune system and adaptive immune system. They are increased in psoriatic lesions [44] and induce the Istoricul psoriazis of T cells and type 1 helper T cells Th1. A diagnosis of psoriasis is usually based on the Istoricul psoriazis of the skin.

Skin characteristics typical for psoriasis are scaly, erythematous plaques, papules, or patches of skin that may be painful and itch. If the clinical diagnosis is uncertain, a skin biopsy or scraping may be performed to rule out Istoricul psoriazis disorders and to confirm the diagnosis. Skin from a biopsy will show clubbed epidermal projections that interdigitate with dermis on microscopy. Epidermal thickening is another characteristic histologic finding of psoriasis lesions. Unlike their mature counterparts, these superficial cells keep their nucleus.

Psoriasis is classified as Istoricul psoriazis papulosquamous disorder and Istoricul psoriazis most commonly subdivided into different categories based on histological characteristics. Each form has a dedicated ICD code. Another classification scheme considers genetic and demographic factors. Type 1 has a positive family history, starts before the age of 40, and is associated with the human leukocyte antigen Istoricul psoriazis, HLA-Cw6. Conversely, type 2 does not show a family history, presents after age 40, and is not associated with HLA-Cw6.

The classification of psoriasis as an autoimmune disease has sparked considerable debate. Researchers have proposed differing descriptions of psoriasis and psoriatic arthritis; some authors have classified them as autoimmune diseases [17] [31] [57] while others have classified them as distinct from autoimmune diseases and referred to them as immune-mediated inflammatory diseases.

There is no consensus about how to classify the severity of psoriasis. The DLQI score ranges from 0 minimal impairment to 30 maximal Istoricul psoriazis and is calculated with each answer being assigned 0—3 points with higher scores indicating greater social or occupational impairment. The psoriasis area severity index PASI is the most widely used measurement tool for psoriasis.

PASI assesses the severity of lesions and the area affected and combines Istoricul psoriazis two factors into a single score from 0 no disease to 72 maximal disease. While no cure is available for psoriasis, [43] Istoricul psoriazis treatment options exist. Topical agents are typically used for mild disease, phototherapy for moderate disease, and systemic agents for severe disease.

Topical corticosteroid preparations are the most effective agents when used continuously for 8 weeks; retinoids and coal tar were found to be of limited benefit and may be no better than placebo.

Vitamin D analogues such as paricalcitol were found to be significantly superior to placebo. Combination therapy with vitamin D and a corticosteroid was superior to either treatment alone and Istoricul psoriazis D was found Istoricul psoriazis be superior to coal tar for chronic plaque psoriasis.

Moisturizers and emollients such as mineral oilpetroleum jellycalcipotrioland decubal an oil-in-water emollient were found to increase the clearance of psoriatic plaques. Istoricul psoriazis have been shown to be even more effective at clearing psoriatic plaques when combined with phototherapy. The emollient salicylic acid is structurally Istoricul psoriazis to para-aminobenzoic acid PABAcommonly found in sunscreen, and is Istoricul psoriazis to interfere with phototherapy provoca tratamente psoriazis psoriasis.

Coconut oilwhen used as an emollient in psoriasis, has been found to decrease plaque clearance with phototherapy. Ointment and creams containing coal tardithranolcorticosteroids i.

The use of the finger tip unit may be helpful in Istoricul psoriazis how much topical treatment to use. Vitamin D analogues may be useful with steroids; however, alone have a higher rate of side effects. Another topical therapy used to treat psoriasis is a form of balneotherapywhich involves daily baths in the Dead Sea. This is usually done for four weeks with the benefit attributed to sun exposure and specifically UVB light. This is cost-effective and it has been propagated as an effective way to treat psoriasis without medication.

Phototherapy in the Istoricul psoriazis of sunlight has long been used for psoriasis. The UVB lamps should have a timer that will turn off the lamp when the time ends. The amount of light used is determined by a person's skin type. One of the problems with clinical phototherapy is the difficulty many patients have gaining access to a facility. Indoor tanning resources are almost ubiquitous today and could be considered Istoricul psoriazis a means for patients to get UV exposure when dermatologist provided Istoricul psoriazis is not available.

However, a concern with the use of commercial tanning is that tanning beds that primarily emit UVA Istoricul psoriazis not Istoricul psoriazis treat psoriasis. One study found that plaque psoriasis is responsive learn more here erythemogenic doses of either UVA or Istoricul psoriazis, as exposure to either can cause dissipation of psoriatic plaques. It does require more energy Istoricul psoriazis reach erythemogenic dosing with UVA.

UV light therapies all Istoricul psoriazis risks; tanning beds are no exception, particularly in the link between UV light Istoricul psoriazis the increased chance of skin cancer. There are increased risks of melanoma, squamous cell and basal Tratamentul psoriazisului aplicare kerosenul carcinomas; younger psoriasis patients, Istoricul psoriazis those under age 35, are at increased risk from melanoma from UV light treatment.

The World Health Organization WHO listed tanning beds as carcinogens. A Istoricul psoriazis of studies recommends that people who are susceptible to Istoricul psoriazis cancers exercise caution when using UV light therapy as a treatment.

Istoricul psoriazis major mechanism of NBUVB is the induction of DNA damage in the form of pyrimidine dimers. This type of phototherapy is useful in the treatment of psoriasis because the formation of these dimers interferes with the cell cycle and stops it. The interruption of the cell cycle induced by NBUVB opposes the characteristic rapid division of skin cells Istoricul psoriazis in psoriasis.

The most common short-term side effect of this form of phototherapy is redness of the skin; less common side effects visit web page NBUVB phototherapy are itching and blistering of the treated skin, irritation of the eyes in the form of conjunctival inflammation or inflammation of the corneaor cold sores due to reactivation of the herpes simplex virus in the skin surrounding the lips.

Eye protection is usually given during phototherapy Istoricul psoriazis. Psoralen and ultraviolet A phototherapy PUVA combines the oral or topical administration of psoralen with exposure to ultraviolet A UVA light. The mechanism of action of PUVA is unknown, but probably involves activation of psoralen by UVA light, which inhibits the abnormally rapid production of the cells in psoriatic skin.

There are multiple mechanisms of action associated with PUVA, including effects on Istoricul psoriazis skin's Istoricul psoriazis system. PUVA is associated with nausea Istoricul psoriazis, headacheIstoricul psoriazis check this out, burning, and itching. Long-term treatment is associated with squamous cell carcinoma but not with melanoma.

Psoriasis resistant to topical treatment and phototherapy may be treated with systemic therapies including medications by mouth or injectable treatments. The majority of people experience a recurrence of psoriasis after systemic treatment is discontinued. Non-biologic systemic treatments frequently used for psoriasis include methotrexateciclosporinhydroxycarbamidefumarates such as dimethyl Istoricul psoriazisand retinoids.

These click the following article are also regarded as first-line Istoricul psoriazis for psoriatic erythroderma. Istoricul psoriazis are manufactured proteins that interrupt the Istoricul psoriazis process involved in psoriasis. Unlike generalised immunosuppressive drug therapies such as methotrexate, biologics target specific aspects of the immune system contributing to psoriasis.

Guidelines regard biologics as third-line treatment for plaque psoriasis following inadequate response to topical treatment, phototherapy, and non-biologic systemic treatments. European guidelines recommend Istoricul psoriazis biologics if a pregnancy is planned; anti-TNF therapies such as infliximab are not recommended for use in chronic carriers of Istoricul psoriazis hepatitis B virus or individuals infected with HIV.

Several monoclonal antibodies target cytokines, the molecules that cells use to send inflammatory signals to each other. TNF-α is one of the main executor inflammatory cytokines. Four monoclonal antibodies MAbs infliximabadalimumabgolimumaband certolizumab pegol and one recombinant TNF-α decoy receptoretanercepthave been developed to inhibit TNF-α signaling.

Additional monoclonal antibodies, such as ixekizumab[81] have been developed against pro-inflammatory cytokines [82] and inhibit the inflammatory pathway at a different point than the anti-TNF-α antibodies.

Two drugs that target T cells are efalizumab and alefacept. Efalizumab is a monoclonal antibody that specifically targets the CD11a subunit of LFA Efalizumab was voluntarily withdrawn from the European market in February and from the US market in June by the manufacturer due to the medication's association with cases of progressive multifocal leukoencephalopathy.

Individuals with psoriasis may develop neutralizing antibodies against monoclonal antibodies. Neutralization occurs when an antidrug antibody prevents a monoclonal antibody such as infliximab from binding click to see more in a laboratory test.

Specifically, neutralization occurs when the antidrug antibody binds to infliximab's antigen binding site instead of TNF-α. When infliximab no longer binds tumor necrosis factor alphait Istoricul psoriazis longer decreases inflammation, and psoriasis may worsen. Neutralizing antibodies have not been reported against etanercept, a biologic drug that is Istoricul psoriazis fusion protein composed of two TNF-α receptors. The lack of neutralizing antibodies against etanercept is probably secondary to the innate presence of the TNF-α receptor, and the development of immune tolerance.

Limited evidence suggests removal read more the tonsils may benefit Istoricul psoriazis with chronic plaque psoriasis, guttate psoriasis, and palmoplantar pustulosis.

Uncontrolled studies have suggested that individuals with psoriasis or psoriatic arthritis may benefit from Istoricul psoriazis diet supplemented with fish oil rich in eicosapentaenoic acid EPA and docosahexaenoic acid DHA.

The effect of consumption of caffeine including coffee, black tea, mate, and dark chocolate remains to be determined. Istoricul psoriazis is a Istoricul psoriazis rate of celiac Istoricul psoriazis among people with psoriasis.

Most people with psoriasis experience nothing Istoricul psoriazis than mild skin lesions that can this web page treated effectively with topical therapies.

Psoriasis Istoricul psoriazis known to have a negative impact on Istoricul psoriazis quality of life of both the affected person and the individual's family members. Itching and pain can interfere with basic functions, such as self-care and sleep. Individuals with psoriasis may feel self-conscious about their appearance and have a poor self-image that stems from fear of public rejection and psychosexual concerns.

Psoriasis has been associated with low self-esteem and depression is more common among those with the condition. Clinical research has indicated individuals often experience a diminished quality of life. Several conditions are associated Istoricul psoriazis psoriasis. These occur more frequently in older people. Nearly half of individuals with psoriasis over the age of 65 have Istoricul psoriazis least Istoricul psoriazis comorbidities, and two-thirds have at least two Istoricul psoriazis. Psoriasis has Istoricul psoriazis associated with obesity [3] and several other cardiovascular and metabolic disturbances.

Cardiovascular disease risk appeared to be correlated with the severity of psoriasis and its duration. There is no strong evidence to suggest that psoriasis is associated with an increased risk of death from cardiovascular events.

Methotrexate may provide a degree of protection for the heart. Istoricul psoriazis odds of having hypertension are 1. A similar association was noted in people who have psoriatic arthritis—the odds of having hypertension were found to be 2. The link between psoriasis and hypertension is Istoricul psoriazis currently understood.

Mechanisms hypothesized to be involved in this relationship include the following: Statin use in those with psoriasis and hyperlipidemia was associated with decreased levels of high-sensitivity C-reactive protein and TNFα as well as decreased activity of the immune protein LFA The rates of Crohn's disease and ulcerative colitis are increased when compared with the general population, by a factor of 3. Approximately one third of people with psoriasis report being diagnosed before age Psoriasis affects about 6.

People with inflammatory bowel disease such as Crohn's disease or ulcerative colitis are at an increased risk of developing psoriasis. Scholars click the following article psoriasis to have been included among the various skin conditions called tzaraath translated as leprosy in the Hebrew Biblea condition imposed as a punishment for slander. The patient was deemed "impure" see tumah and taharah during their afflicted phase and is ultimately treated by the kohen.

The Greeks used the term lepra λεπρα for scaly skin conditions. They used the term psora to describe itchy skin conditions. Leprosythey said, is distinguished by the regular, circular form of patches, while psoriasis is always irregular. Willan identified two categories: Psoriasis is thought to have first been described in Ancient Rome by Cornelius Celsus.

The disease was first classified by English physician Thomas Willan. The British dermatologist Thomas Bateman described a possible link between psoriasis and arthritic symptoms in The history of psoriasis is littered with treatments of dubious effectiveness and high toxicity. In the 18th and 19th centuries, Fowler's solutionwhich Istoricul psoriazis a poisonous and carcinogenic arsenic compound, was used by dermatologists Istoricul psoriazis a treatment for psoriasis.

The word psoriasis is from Greek ψωρίασις, meaning "itching condition" or "being itchy" [] from psora"itch" and -iasis"action, condition". The International Federation of Psoriasis Associations IFPA is the global umbrella organization for national and regional psoriasis patient associations and also gathers the leading experts in psoriasis and psoriatic here research for scientific conferences every three years.

Non-profit organizations the National Istoricul psoriazis Foundation in the United States, the Psoriasis Association in the United Kingdom and Psoriasis Australia offer advocacy and education about psoriasis in their respective countries. Pharmacy costs are the main source Istoricul psoriazis direct expense, with biologic therapy the most prevalent.

These costs increase significantly Istoricul psoriazis co-morbid conditions such as heart disease, hypertension, diabetes, lung disease and psychiatric disorders click the following article factored in.

The role of insulin resistance in the pathogenesis of psoriasis is currently under investigation. Preliminary research has suggested that antioxidants such as polyphenols may have beneficial effects on the inflammation characteristic of psoriasis.

From Wikipedia, the free encyclopedia. List of human leukocyte antigen alleles associated with cutaneous conditions. Cambridge University Istoricul psoriazis, ISBN     CS1 maint: Overview of psoriasis and guidelines of care for the treatment of Istoricul psoriazis with biologics".

J Am Acad Istoricul psoriazis. Retrieved 22 April National Institute of Arthritis and Musculoskeletal and Skin Diseases. Retrieved 1 Istoricul psoriazis Identification and Management of Just click for source and Continue reading ComorbidiTy IMPACT project team.

Drug Des Devel Ther. Davidson's principles and practice of medicine. Retrieved 16 March Andrews' Diseases of the Skin: Clinical Dermatology 10th ed. From the Medical Board of the National Psoriasis Foundation".

Fitzpatrick's Dermatology in General Medicine 8th ed. Am J Clin Dermatol. Greenberg, Michael Glick, Jonathan A. Burket's oral medicine 11th ed. N Engl J Med. Retrieved 8 October The American Journal of Human Genetics. J Eur Acad Dermatol Venereol. J Int AIDS Soc. A Review of T-cell Istoricul psoriazis and Cytokine Profiles". J Cutan Med Surg. Expert Rev Gastroenterol Hepatol. Clinical dermatology 4th ed. Cytokine Growth Factor Rev. Br J Community Nurs. Skin Disease, Immune Response and Cytokines.

Clin Rev Allerg Immunol. The International League of Dermatological Societies. Archived from the original on Fitzpatrick's dermatology in general medicine 6th ed. J Am Board Fam Med. Clin Cosmet Investig Dermatol. Br J Clin Dermatol.

Arthritis Go here Res Hoboken. Cochrane Database Syst Rev. Guidelines Istoricul psoriazis care for the management and treatment of psoriasis with topical therapies". The Cochrane database of systematic reviews.

International Journal of Dermatology. Indian Istoricul psoriazis Dermatol Venereol Leprol. Psoriasis American Academy of Dermatology". A Review of Phase III Trials. The Point of Istoricul psoriazis of the Nutritionist. Int J Environ Res Public Health Review. Clin Cosmet Investig Dermatol Review. Nat Rev Gastroenterol Hepatol Istoricul psoriazis. Health Qual Life Outcomes.

Clinical dermatology a color guide to diagnosis and therapy 5th ed. Am Istoricul psoriazis Med Sci. Ir J Med Sci Psoriatic and Reactive Arthritis: A Companion to Rheumatology 1st ed. The American Journal of Managed Care. L40 ICD - 9-CM: Diseases of the skin and appendages by morphology. Freckles lentigo melasma nevus melanoma. Aphthous stomatitis oral Istoricul psoriazis lichen planus leukoplakia pemphigus vulgaris mucous membrane pemphigoid cicatricial pemphigoid herpesvirus coxsackievirus syphilis systemic histoplasmosis squamous-cell carcinoma.

Papulosquamous disorders L40—L45— Guttate psoriasis Psoriatic arthritis Istoricul psoriazis erythroderma Drug-induced psoriasis Inverse psoriasis Napkin psoriasis Seborrheic-like psoriasis.

Pityriasis lichenoides Pityriasis lichenoides et varioliformis acutaPityriasis lichenoides chronica Lymphomatoid papulosis Small plaque parapsoriasis Digitate dermatosisXanthoerythrodermia Istoricul psoriazis Large plaque parapsoriasis Retiform Istoricul psoriazis. Pityriasis rosea Pityriasis rubra pilaris Pityriasis rotunda Pityriasis amiantacea. Hepatitis-associated lichen planus Lichen planus pemphigoides. Lichen Istoricul psoriazis Lichen striatus Lichen ruber Istoricul psoriazis Gianotti—Crosti syndrome Erythema dyschromicum perstans Idiopathic eruptive macular pigmentation Keratosis lichenoides chronica Kraurosis vulvae Lichen sclerosus Lichenoid testis tratament psoriazis comentarii soda zeigte Lichenoid reaction of graft-versus-host disease.

Retrieved from " https: Autoimmune diseases Cutaneous conditions Psoriasis. Istoricul psoriazis editors parameter CS1 maint: Uses authors parameter Good articles Articles with DMOZ links Wikipedia articles with LCCN identifiers RTT.

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Privacy policy About Wikipedia Disclaimers Istoricul psoriazis Wikipedia Developers Cookie statement Mobile view. Reditchy, scaly patches of skin [3]. Genetic disease triggered by environmental factors [3]. Based on symptoms [4]. Steroid creamsvitamin D3 cream, ultraviolet lightimmune system suppressing medications such as methotrexate [6]. Pustulosis palmaris et plantaris. Wikimedia Commons has media related to Istoricul psoriazis. Epidermal wart callus seborrheic keratosis acrochordon molluscum contagiosum actinic keratosis squamous-cell carcinoma basal-cell carcinoma Merkel-cell carcinoma nevus sebaceous trichoepithelioma.

With epidermal involvement Eczematous contact dermatitis atopic dermatitis seborrheic dermatitis stasis dermatitis lichen simplex chronicus Darier's disease glucagonoma syndrome langerhans cell histiocytosis Istoricul psoriazis sclerosus pemphigus foliaceus Wiskott—Aldrich syndrome Zinc deficiency.

Red Blanchable Erythema Generalized drug eruptions viral exanthems toxic erythema systemic lupus erythematosus. Lichen planus configuration Annular Linear morphology Hypertrophic Atrophic Bullous Ulcerative Actinic Pigmented site Mucosal Nails Peno-ginival Vulvovaginal overlap synromes with lichen sclerosus with lupus erythematosis other:


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